1VIE

STRUCTURE OF DIHYDROFOLATE REDUCTASE

Summary for 1VIE

Entry DOI	10.2210/pdb1vie/pdb
Descriptor	DIHYDROFOLATE REDUCTASE (2 entities in total)
Functional Keywords	oxidoreductase, nadp, trimethoprim resistance, methotrexate resistance, one-carbon metabolism, plasmid
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	6732.53
Authors	Narayana, N.,Matthews, D.A.,Howell, E.E.,Xuong, N.-H. (deposition date: 1996-10-03, release date: 1997-10-22, Last modification date: 2024-02-14)
Primary citation	Narayana, N.,Matthews, D.A.,Howell, E.E.,Nguyen-huu, X. A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site. Nat.Struct.Biol., 2:1018-1025, 1995 Cited by PubMed: 7583655 DOI: 10.1038/nsb1195-1018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation