1VGN

Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)

Summary for 1VGN

• Entry DOI: 10.2210/pdb1vgn/pdb
• Descriptor: Beta-lactamase IMP-1, ZINC ION, 3-OXO-3-[(3-OXOPROPYL)SULFANYL]PROPANE-1-THIOLATE, ... (5 entities in total)
• Functional Keywords: metallo-beta-lactamase, zinc, irreversible inhibitor, hydrolase
• Biological source: Serratia marcescens
• Total number of polymer chains: 2
• Total formula weight: 50969.57

Authors

Kurosaki, H.,Yamaguchi, Y.,Higashi, T.,Soga, K.,Matsueda, S.,Misumi, S.,Yamagata, Y.,Arakawa, Y.,Goto, M. (deposition date: 2004-04-27, release date: 2005-06-21, Last modification date: 2024-10-30)

• Primary citation: Kurosaki, H.,Yamaguchi, Y.,Higashi, T.,Soga, K.,Matsueda, S.,Yumoto, H.,Misumi, S.,Yamagata, Y.,Arakawa, Y.,Goto, M.; Irreversible Inhibition of Metallo-beta-lactamase (IMP-1) by 3-(3-Mercaptopropionylsulfanyl)propionic Acid Pentafluorophenyl Ester; Angew.Chem.Int.Ed.Engl., 44:3861-3864, 2005; PubMed: 15892033; DOI: 10.1002/anie.200500835

Experimental method

X-RAY DIFFRACTION (2.63 Å)