1VFE

HUMAN LACTOFERRIN, N-TERMINAL LOBE MUTANT WITH ARG 121 REPLACED BY SER (R121S)

1VFE の概要

• エントリーDOI: 10.2210/pdb1vfe/pdb
• 分子名称: HUMAN LACTOFERRIN, FE (III) ION, CARBONATE ION, ... (4 entities in total)
• 機能のキーワード: transferrin, iron transport, glycoprotein, metal-binding, recombinant half molecule, mutant
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Secreted. Isoform DeltaLf: Cytoplasm: P02788
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37066.77

構造登録者

Faber, H.R.,Day, C.L.,Baker, E.N. (登録日: 1996-10-01, 公開日: 1997-04-01, 最終更新日: 2023-08-09)

• 主引用文献: Faber, H.R.,Baker, C.J.,Day, C.L.,Tweedie, J.W.,Baker, E.N.; Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants.; Biochemistry, 35:14473-14479, 1996; PubMed: 8931543; DOI: 10.1021/bi961729g

実験手法

X-RAY DIFFRACTION (2.3 Å)