Loading
PDBj
メニューPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

1VDR

DIHYDROFOLATE REDUCTASE

1VDR の概要
エントリーDOI10.2210/pdb1vdr/pdb
分子名称DIHYDROFOLATE REDUCTASE, PHOSPHATE ION (3 entities in total)
機能のキーワードoxidoreductase, dihydrofolate reductase, halophilic enzyme
由来する生物種Haloferax volcanii
タンパク質・核酸の鎖数2
化学式量合計36280.56
構造登録者
Pieper, U.,Herzberg, O. (登録日: 1997-11-30, 公開日: 1998-02-25, 最終更新日: 2024-05-22)
主引用文献Pieper, U.,Kapadia, G.,Mevarech, M.,Herzberg, O.
Structural features of halophilicity derived from the crystal structure of dihydrofolate reductase from the Dead Sea halophilic archaeon, Haloferax volcanii.
Structure, 6:75-88, 1998
Cited by
PubMed Abstract: The proteins of halophilic archaea require high salt concentrations both for stability and for activity, whereas they denature at low ionic strength. The structural basis for this phenomenon is not yet well understood. The crystal structure of dihydrofolate reductase (DHFR) from Haloferax volcanii (hv-DHFR) reported here provides the third example of a structure of a protein from a halophilic organism. The enzyme is considered moderately halophilic, as it retains activity and secondary structure at monovalent salt concentrations as low as 0.5 M.
PubMed: 9493269
DOI: 10.1016/S0969-2126(98)00009-4
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.55 Å)
構造検証レポート
Validation report summary of 1vdr
検証レポート(詳細版)ダウンロードをダウンロード

243083

件を2025-10-15に公開中

PDB statisticsPDBj update infoContact PDBjnumon