1VAQ

Crystal structure of the Mg2+-(chromomycin A3)2-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by metal ion

Summary for 1VAQ

• Entry DOI: 10.2210/pdb1vaq/pdb
• Descriptor: 5'-D(*TP*TP*GP*GP*CP*CP*AP*A)-3', 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, ... (6 entities in total)
• Functional Keywords: chromomycin a3, mad, dna duplex, ggcc site, dna kink, cd spectra, dna
• Biological source: synthetic construct
• Total number of polymer chains: 4
• Total formula weight: 14440.19

Authors

Hou, M.H.,Robinson, H.,Gao, Y.G.,Wang, A.H.-J. (deposition date: 2004-02-19, release date: 2004-06-22, Last modification date: 2023-12-27)

• Primary citation: Hou, M.H.,Robinson, H.,Gao, Y.G.,Wang, A.H.-J.; Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion; Nucleic Acids Res., 32:2214-2222, 2004; PubMed: 15107489; DOI: 10.1093/nar/gkh549

Experimental method

X-RAY DIFFRACTION (2 Å)