1V33

Crystal structure of DNA primase from Pyrococcus horikoshii

1V33 の概要

• エントリーDOI: 10.2210/pdb1v33/pdb
• 関連するPDBエントリー: 1V34
• 分子名称: DNA primase small subunit, ZINC ION, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: nucleotidyl transferase, riken structural genomics/proteomics initiative, rsgi, structural genomics, transferase
• 由来する生物種: Pyrococcus horikoshii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42803.46

構造登録者

Ito, N.,Nureki, O.,Shirouzu, M.,Yokoyama, S.,Hanaoka, F.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2003-10-25, 公開日: 2004-03-23, 最終更新日: 2023-12-27)

主引用文献

Ito, N.,Nureki, O.,Shirouzu, M.,Yokoyama, S.,Hanaoka, F.
Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis.
Genes Cells, 8:913-923, 2003

PubMed Abstract: In chromosomal DNA replication, DNA primase initiates the synthesis of a dinucleotide on a single-stranded template DNA, and elongates it to form a primer RNA for the replicative DNA polymerase. Although the apo-structure of an archaeal primase has been reported, the mechanism of primer synthesis by the eukaryotic-type primase still remains to be elucidated.

PubMed: 14750947
DOI: 10.1111/j.1365-2443.2003.00693.x

実験手法

X-RAY DIFFRACTION (1.8 Å)