1UWB

TYR 181 CYS HIV-1 RT/8-CL TIBO

Summary for 1UWB

• Entry DOI: 10.2210/pdb1uwb/pdb
• Descriptor: REVERSE TRANSCRIPTASE, 5-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE (3 entities in total)
• Functional Keywords: aids, polyprotein, hydrolase, aspartyl protease, endonuclease, rna-directed dna polymerase, tyr181cys hiv-1 rt/8-cl tibo, drug-resistant mutant
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 114387.82

Authors

Das, K.,Ding, J.,Hsiou, Y.,Arnold, E. (deposition date: 1996-11-21, release date: 1997-05-15, Last modification date: 2024-02-14)

• Primary citation: Das, K.,Ding, J.,Hsiou, Y.,Clark Jr., A.D.,Moereels, H.,Koymans, L.,Andries, K.,Pauwels, R.,Janssen, P.A.,Boyer, P.L.,Clark, P.,Smith Jr., R.H.,Kroeger Smith, M.B.,Michejda, C.J.,Hughes, S.H.,Arnold, E.; Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.; J.Mol.Biol., 264:1085-1100, 1996; PubMed: 9000632; DOI: 10.1006/jmbi.1996.0698

Experimental method

X-RAY DIFFRACTION (3.2 Å)