1UVS

BOVINE THROMBIN--BM51.1011 COMPLEX

1UVS の概要

• エントリーDOI: 10.2210/pdb1uvs/pdb
• 分子名称: THROMBIN, [[CYCLOHEXANESULFONYL-GLYCYL]-3[PYRIDIN-4-YL-AMINOMETHYL]ALANYL]PIPERIDINE, ... (4 entities in total)
• 機能のキーワード: serine protease, hydrolase, thrombin, blood coagulation
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34343.37

構造登録者

Engh, R.A.,Huber, R. (登録日: 1996-10-16, 公開日: 1997-11-19, 最終更新日: 2024-11-06)

主引用文献

Engh, R.A.,Brandstetter, H.,Sucher, G.,Eichinger, A.,Baumann, U.,Bode, W.,Huber, R.,Poll, T.,Rudolph, R.,von der Saal, W.
Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design.
Structure, 4:1353-1362, 1996

PubMed Abstract: The explosive growth in the rate of X-ray determination of protein structures is fuelled largely by the expectation that structural information will be useful for pharmacological and biotechnological applications. For example, there have been intensive efforts to develop orally administrable antithrombotic drugs using information about the crystal structures of blood coagulation factors, including thrombin. Most of the low molecular weight thrombin inhibitors studied so far are based on arginine and benzamidine. We sought to expand the database of information on thrombin-inhibitor binding by studying new classes of inhibitors.

PubMed: 8939759
DOI: 10.1016/S0969-2126(96)00142-6

実験手法

X-RAY DIFFRACTION (2.8 Å)