1UVQ

Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide

Summary for 1UVQ

DescriptorHLA CLASS II HISTOCOMPATIBILITY ANTIGEN, OREXIN, GLYCINE, ... (10 entities in total)
Functional Keywordsimmunology, mhc class ii, diabetes, narcolepsy, autoimmune disease, structural proteomics in europe, spine, structural genomics, immune system
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains3
Total molecular weight49839.58
Authors
Siebold, C.,Hansen, B.E.,Wyer, J.R.,Harlos, K.,Esnouf, R.E.,Svejgaard, A.,Bell, J.I.,Strominger, J.L.,Jones, E.Y.,Fugger, L. (deposition date: 2004-01-22, release date: 2004-02-05, Last modification date: 2015-10-21)
Primary citation
Siebold, C.,Hansen, B.E.,Wyer, J.R.,Harlos, K.,Esnouf, R.E.,Svejgaard, A.,Bell, J.I.,Strominger, J.L.,Jones, E.Y.,Fugger, L.
Crystal Structure of Hla-Dq0602 that Protects Against Type 1 Diabetes and Confers Strong Susceptibility to Narcolepsy
Proc.Natl.Acad.Sci.USA, 101:1999-, 2004
PubMed: 14769912 (PDB entries with the same primary citation)
DOI: 10.1073/PNAS.0308458100
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers40.3%06.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution