1UVQ

Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide

Summary for 1UVQ

• Entry DOI: 10.2210/pdb1uvq/pdb
• Descriptor: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, OREXIN, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: immunology, mhc class ii, diabetes, narcolepsy, autoimmune disease, structural proteomics in europe, spine, structural genomics, immune system
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 3
• Total formula weight: 49785.54

Authors

Siebold, C.,Hansen, B.E.,Wyer, J.R.,Harlos, K.,Esnouf, R.E.,Svejgaard, A.,Bell, J.I.,Strominger, J.L.,Jones, E.Y.,Fugger, L. (deposition date: 2004-01-22, release date: 2004-02-05, Last modification date: 2020-07-29)

• Primary citation: Siebold, C.,Hansen, B.E.,Wyer, J.R.,Harlos, K.,Esnouf, R.E.,Svejgaard, A.,Bell, J.I.,Strominger, J.L.,Jones, E.Y.,Fugger, L.; Crystal Structure of Hla-Dq0602 that Protects Against Type 1 Diabetes and Confers Strong Susceptibility to Narcolepsy; Proc.Natl.Acad.Sci.USA, 101:1999-, 2004; PubMed: 14769912; DOI: 10.1073/PNAS.0308458100

Experimental method

X-RAY DIFFRACTION (1.8 Å)