1UV0

Pancreatitis-associated protein 1 from human

Summary for 1UV0

• Entry DOI: 10.2210/pdb1uv0/pdb
• Descriptor: PANCREATITIS-ASSOCIATED PROTEIN 1, ZINC ION (3 entities in total)
• Functional Keywords: lectin, c-type, secreted, inflammatory response, acute phase, sugar binding protein
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 16780.68

Authors

Abergel, C.,Shepard, W.,Christal, L. (deposition date: 2004-01-12, release date: 2004-01-14, Last modification date: 2024-11-20)

Primary citation

Abergel, C.,Chenivesse, S.,Stinnakre, M.G.,Guasco, S.,Brechot, C.,Claverie, J.M.,Devinoy, E.,Christa, L.
Crystallization and preliminary crystallographic study of HIP/PAP, a human C-lectin overexpressed in primary liver cancers.
Acta Crystallogr.,Sect.D, 55:1487-1489, 1999

PubMed Abstract: Human HIP/PAP is an adhesion protein expressed in normal pancreatic and Paneth cells and overexpressed in hepatocellular carcinoma. HIP/PAP was crystallized using the Hampton Research Crystal Screen and SAmBA software to define the optimal crystallization protocol. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 30.73, b = 49.35, c = 92.15 A and one molecule in the asymmetric unit. Flash-frozen crystals diffract to 1. 78 A resolution using synchrotron radiation. A molecular-replacement solution was obtained using the human Reg/lithostathine structure and the AMoRe software.

PubMed: 10417404
DOI: 10.1107/s0907444999007969

Experimental method

X-RAY DIFFRACTION (1.78 Å)