1UUI
NMR structure of a synthetic small molecule, rbt158, bound to HIV-1 TAR RNA
Summary for 1UUI
Entry DOI | 10.2210/pdb1uui/pdb |
Related | 1UTS 1UUD |
Descriptor | 5'-R(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP*CP* CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C)-3', 4-[AMINO(IMINO)METHYL]-1-[2-(3-AMMONIOPROPOXY)-5-METHOXYBENZYL]PIPERAZIN-1-IUM (2 entities in total) |
Functional Keywords | hiv-1, tar rna, drug design, ligand-rna interaction, rna bulge, inhibitor |
Biological source | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (CLONE 12) |
Total number of polymer chains | 1 |
Total formula weight | 9630.99 |
Authors | Davis, B.,Afshar, M.,Varani, G.,Karn, J.,Murchie, A.I.H.,Lentzen, G.,Drysdale, M.J.,Potter, A.J.,Bower, J.,Aboul-Ela, F. (deposition date: 2003-12-19, release date: 2004-02-12, Last modification date: 2024-05-15) |
Primary citation | Davis, B.,Afshar, M.,Varani, G.,Murchie, A.I.H.,Karn, J.,Lentzen, G.,Drysdale, M.J.,Bower, J.,Potter, A.J.,Aboul-Ela, F. Rational Design of Inhibitors of HIV-1 Tar RNA Through the Stabilisation of Electrostatic "Hot Spots" J.Mol.Biol., 336:343-, 2004 Cited by PubMed: 14757049DOI: 10.1016/J.JMB.2003.12.046 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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