1UUI

NMR structure of a synthetic small molecule, rbt158, bound to HIV-1 TAR RNA

Summary for 1UUI

• Entry DOI: 10.2210/pdb1uui/pdb
• Related: 1UTS 1UUD
• Descriptor: 5'-R(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP*CP* CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C)-3', 4-[AMINO(IMINO)METHYL]-1-[2-(3-AMMONIOPROPOXY)-5-METHOXYBENZYL]PIPERAZIN-1-IUM (2 entities in total)
• Functional Keywords: hiv-1, tar rna, drug design, ligand-rna interaction, rna bulge, inhibitor
• Biological source: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (CLONE 12)
• Total number of polymer chains: 1
• Total formula weight: 9630.99

Authors

Davis, B.,Afshar, M.,Varani, G.,Karn, J.,Murchie, A.I.H.,Lentzen, G.,Drysdale, M.J.,Potter, A.J.,Bower, J.,Aboul-Ela, F. (deposition date: 2003-12-19, release date: 2004-02-12, Last modification date: 2011-07-13)

• Primary citation: Davis, B.,Afshar, M.,Varani, G.,Murchie, A.I.H.,Karn, J.,Lentzen, G.,Drysdale, M.J.,Bower, J.,Potter, A.J.,Aboul-Ela, F.; Rational Design of Inhibitors of HIV-1 Tar RNA Through the Stabilisation of Electrostatic "Hot Spots"; J.Mol.Biol., 336:343-, 2004; PubMed: 14757049; DOI: 10.1016/J.JMB.2003.12.046

Experimental method

SOLUTION NMR