1UTR

UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)

1UTR の概要

• エントリーDOI: 10.2210/pdb1utr/pdb
• 分子名称: UTEROGLOBIN, 4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL (2 entities in total)
• 機能のキーワード: uteroglobin, clara cell 17 kda protein (cc10), phospholipase a2 inhibitor, clara cell phospholipid-binding protein, progesterone binding, mammalian pcb-binding protein
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Secreted: P17559
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 21362.58

構造登録者

Hard, T.,Barnes, H.J.,Larsson, C.,Gustafsson, J.-A.,Lund, J. (登録日: 1995-09-01, 公開日: 1995-12-07, 最終更新日: 2024-05-22)

主引用文献

Hard, T.,Barnes, H.J.,Larsson, C.,Gustafsson, J.A.,Lund, J.
Solution structure of a mammalian PCB-binding protein in complex with a PCB.
Nat.Struct.Biol., 2:983-989, 1995

PubMed Abstract: Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin, a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds. Breakage of these bonds induces a local unfolding of the N- and C-termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand.

PubMed: 7583672
DOI: 10.1038/nsb1195-983

実験手法

SOLUTION NMR