1USN

CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-142372

1USN の概要

• エントリーDOI: 10.2210/pdb1usn/pdb
• 分子名称: STROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase, metalloprotease, fibroblast, collagen degradation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix : P08254
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19339.52

構造登録者

Finzel, B.C.,Bryant Junior, G.L.,Baldwin, E.T. (登録日: 1998-06-09, 公開日: 1998-12-23, 最終更新日: 2023-08-09)

• 主引用文献: Finzel, B.C.,Baldwin, E.T.,Bryant Jr., G.L.,Hess, G.F.,Wilks, J.W.,Trepod, C.M.,Mott, J.E.,Marshall, V.P.,Petzold, G.L.,Poorman, R.A.,O'Sullivan, T.J.,Schostarez, H.J.,Mitchell, M.A.; Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity.; Protein Sci., 7:2118-2126, 1998; PubMed: 9792098

実験手法

X-RAY DIFFRACTION (1.8 Å)