1UOU

Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor

Summary for 1UOU

Entry DOI	10.2210/pdb1uou/pdb
Descriptor	THYMIDINE PHOSPHORYLASE, 5-CHLORO-6-(1-(2-IMINOPYRROLIDINYL) METHYL) URACIL (3 entities in total)
Functional Keywords	phosphorylase, transferase, glycosyltransferase, chemotaxis, angiogenesis
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	49438.02
Authors	Norman, R.A.,Barry, S.T.,Bate, M.,Breed, J.,Colls, J.G.,Ernill, R.J.,Luke, R.W.A.,Minshull, C.A.,McAlister, M.S.B.,McCall, E.J.,McMiken, H.H.J.,Paterson, D.S.,Timms, D.,Tucker, J.A.,Pauptit, R.A. (deposition date: 2003-09-23, release date: 2004-01-22, Last modification date: 2023-12-13)
Primary citation	Norman, R.A.,Barry, S.T.,Bate, M.,Breed, J.,Colls, J.G.,Ernill, R.J.,Luke, R.W.A.,Minshull, C.A.,Mcalister, M.S.B.,Mccall, E.J.,Mcmicken, H.H.J.,Paterson, D.S.,Timms, D.,Tucker, J.A.,Pauptit, R.A. Crystal Structure of Human Thymidine Phosphorylase in Complex with a Small Molecule Inhibitor Structure, 12:75-, 2004 Cited by PubMed: 14725767 DOI: 10.1016/J.STR.2003.11.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation