1UOT

HUMAN CD55 DOMAINS 3 & 4

1UOT の概要

• エントリーDOI: 10.2210/pdb1uot/pdb
• 関連するPDBエントリー: 1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9
• 分子名称: COMPLEMENT DECAY-ACCELERATING FACTOR (2 entities in total)
• 機能のキーワード: regulator of complement pathway, immune system protein, complement decay accelerating factor, enteroviral receptor, bacterial receptor, ligand for cd97, complement pathway, alternative splicing, gpi-anchor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor: P08174
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13586.05

構造登録者

Williams, P.,Chaudhry, Y.,Goodfellow, I.G.,Billington, J.,Spiller, B.,Evans, D.J.,Lea, S.M. (登録日: 2003-09-23, 公開日: 2003-09-25, 最終更新日: 2024-11-13)

主引用文献

Williams, P.,Chaudhry, Y.,Goodfellow, I.G.,Billington, J.,Powell, R.,Spiller, O.B.,Evans, D.J.,Lea, S.M.
Mapping Cd55 Function. The Structure of Two Pathogen-Binding Domains at 1.7 A
J.Biol.Chem., 278:10691-, 2003

PubMed Abstract: Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.

PubMed: 12499389
DOI: 10.1074/JBC.M212561200

実験手法

X-RAY DIFFRACTION (3 Å)