1UOR

X-RAY STUDY OF RECOMBINANT HUMAN SERUM ALBUMIN. PHASES DETERMINED BY MOLECULAR REPLACEMENT METHOD, USING LOW RESOLUTION STRUCTURE MODEL OF TETRAGONAL FORM OF HUMAN SERUM ALBUMIN

Summary for 1UOR

Entry DOI	10.2210/pdb1uor/pdb
Descriptor	SERUM ALBUMIN (1 entity in total)
Functional Keywords	plasma protein, metal-binding protein, metal binding protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02768
Total number of polymer chains	1
Total formula weight	66571.22
Authors	Carter, D.C.,Ho, J.X. (deposition date: 1998-03-10, release date: 1998-05-27, Last modification date: 2024-11-20)
Primary citation	He, X.M.,Carter, D.C. Atomic structure and chemistry of human serum albumin. Nature, 358:209-215, 1992 Cited by PubMed Abstract: The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin. PubMed: 1630489 DOI: 10.1038/358209a0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation