1UOR

X-RAY STUDY OF RECOMBINANT HUMAN SERUM ALBUMIN. PHASES DETERMINED BY MOLECULAR REPLACEMENT METHOD, USING LOW RESOLUTION STRUCTURE MODEL OF TETRAGONAL FORM OF HUMAN SERUM ALBUMIN

1UOR の概要

• エントリーDOI: 10.2210/pdb1uor/pdb
• 分子名称: SERUM ALBUMIN (1 entity in total)
• 機能のキーワード: plasma protein, metal-binding protein, metal binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02768
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 66571.22

構造登録者

Carter, D.C.,Ho, J.X. (登録日: 1998-03-10, 公開日: 1998-05-27, 最終更新日: 2024-11-20)

主引用文献

He, X.M.,Carter, D.C.
Atomic structure and chemistry of human serum albumin.
Nature, 358:209-215, 1992

PubMed Abstract: The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin.

PubMed: 1630489
DOI: 10.1038/358209a0

実験手法

X-RAY DIFFRACTION (2.8 Å)