1ULB

APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS

1ULB の概要

• エントリーDOI: 10.2210/pdb1ulb/pdb
• 分子名称: PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION, GUANINE (3 entities in total)
• 機能のキーワード: pentosyltransferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton (By similarity): P00491
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32528.13

構造登録者

Ealick, S.E.,Rule, S.A.,Carter, D.C.,Greenhough, T.J.,Babu, Y.S.,Cook, W.J.,Habash, J.,Helliwell, J.R.,Stoeckler, J.D.,Parksjunior, R.E.,Chen, S.-F.,Bugg, C.E. (登録日: 1991-11-05, 公開日: 1993-01-15, 最終更新日: 2024-02-14)

• 主引用文献: Ealick, S.E.,Babu, Y.S.,Bugg, C.E.,Erion, M.D.,Guida, W.C.,Montgomery, J.A.,Secrist 3rd., J.A.; Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.; Proc.Natl.Acad.Sci.USA, 88:11540-11544, 1991; PubMed: 1763067; DOI: 10.1073/pnas.88.24.11540

実験手法

X-RAY DIFFRACTION (2.75 Å)