1ULA

APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS

Replaces:  2PNP

Summary for 1ULA

• Entry DOI: 10.2210/pdb1ula/pdb
• Descriptor: PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION (2 entities in total)
• Functional Keywords: pentosyltransferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton (By similarity): P00491
• Total number of polymer chains: 1
• Total formula weight: 32377.00

Authors

Ealick, S.E.,Rule, S.A.,Carter, D.C.,Greenhough, T.J.,Babu, Y.S.,Cook, W.J.,Habash, J.,Helliwell, J.R.,Stoeckler, J.D.,Parksjunior, R.E.,Chen, S.-F.,Bugg, C.E. (deposition date: 1991-11-05, release date: 1993-01-15, Last modification date: 2024-02-14)

• Primary citation: Ealick, S.E.,Babu, Y.S.,Bugg, C.E.,Erion, M.D.,Guida, W.C.,Montgomery, J.A.,Secrist 3rd., J.A.; Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.; Proc.Natl.Acad.Sci.USA, 88:11540-11544, 1991; PubMed: 1763067; DOI: 10.1073/pnas.88.24.11540

Experimental method

X-RAY DIFFRACTION (2.75 Å)