1UF2

The Atomic Structure of Rice dwarf Virus (RDV)

1UF2 の概要

• エントリーDOI: 10.2210/pdb1uf2/pdb
• 分子名称: Core protein P3, Outer capsid protein P8, Structural protein P7 (3 entities in total)
• 機能のキーワード: virus components, icosahedral virus, virus
• 由来する生物種: Rice dwarf virus; 詳細
• 細胞内の位置: Virion : P22472 P22473; Outer capsid protein P8: Virion : P17379
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 889084.21

構造登録者

Nakagawa, A.,Miyazaki, N.,Taka, J.,Naitow, H.,Ogawa, A.,Fujimoto, Z.,Mizuno, H.,Higashi, T.,Watanabe, Y.,Omura, T.,Cheng, R.H.,Tsukihara, T. (登録日: 2003-05-23, 公開日: 2003-10-14, 最終更新日: 2024-04-03)

主引用文献

Nakagawa, A.,Miyazaki, N.,Taka, J.,Naitow, H.,Ogawa, A.,Fujimoto, Z.,Mizuno, H.,Higashi, T.,Watanabe, Y.,Omura, T.,Cheng, R.H.,Tsukihara, T.
The atomic structure of rice dwarf virus reveals the self-assembly mechanism of component proteins.
Structure, 11:1227-1238, 2003

PubMed Abstract: Rice dwarf virus (RDV), the causal agent of rice dwarf disease, is a member of the genus Phytoreovirus in the family Reoviridae. RDV is a double-shelled virus with a molecular mass of approximately 70 million Dalton. This virus is widely prevalent and is one of the viruses that cause the most economic damage in many Asian countries. The atomic structure of RDV was determined at 3.5 A resolution by X-ray crystallography. The double-shelled structure consists of two different proteins, the core protein P3 and the outer shell protein P8. The atomic structure shows structural and electrostatic complementarities between both homologous (P3-P3 and P8-P8) and heterologous (P3-P8) interactions, as well as overall conformational changes found in P3-P3 dimer caused by the insertion of amino-terminal loop regions of one of the P3 protein into the other. These interactions suggest how the 900 protein components are built into a higher-ordered virus core structure.

PubMed: 14527391
DOI: 10.1016/j.str.2003.08.012

実験手法

X-RAY DIFFRACTION (3.5 Å)