1UAE

STRUCTURE OF UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE

1UAE の概要

• エントリーDOI: 10.2210/pdb1uae/pdb
• 分子名称: UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, [(1R)-1-hydroxypropyl]phosphonic acid, ... (4 entities in total)
• 機能のキーワード: peptidoglycan, transferase, udp-n-acetylglucosamine, fosfomycin
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm (Probable): P0A749
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45618.97

構造登録者

Skarzynski, T. (登録日: 1996-09-30, 公開日: 1997-09-04, 最終更新日: 2024-02-14)

主引用文献

Skarzynski, T.,Mistry, A.,Wonacott, A.,Hutchinson, S.E.,Kelly, V.A.,Duncan, K.
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin.
Structure, 4:1465-1474, 1996

PubMed Abstract: UDP-N-acetylglucosamine enolpyruvyl transferase (MurA), catalyses the first committed step of bacterial cell wall biosynthesis and is a target for the antibiotic fosfomycin. The only other known enolpyruvyl transferase is 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase, an enzyme involved in the shikimic acid pathway and the target for the herbicide glyphosate. Inhibitors of enolpyruvyl transferases are of biotechnological interest as MurA and EPSP synthase are found exclusively in plants and microbes.

PubMed: 8994972
DOI: 10.1016/S0969-2126(96)00153-0

実験手法

X-RAY DIFFRACTION (1.8 Å)