1U9K

Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76

Summary for 1U9K

• Entry DOI: 10.2210/pdb1u9k/pdb
• Descriptor: triggering receptor expressed on myeloid cells 1, ZINC ION (3 entities in total)
• Functional Keywords: activating receptors, trem-1, innate immunity, immune system receptor, immune system
• Biological source: Mus musculus (house mouse)
• Cellular location: Membrane; Single-pass type I membrane protein (By similarity): Q9JKE2
• Total number of polymer chains: 2
• Total formula weight: 26412.54

Authors

Kelker, M.S.,Debler, E.W.,Wilson, I.A. (deposition date: 2004-08-09, release date: 2004-12-14, Last modification date: 2024-11-20)

Primary citation

Kelker, M.S.,Debler, E.W.,Wilson, I.A.
Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76A
J.Mol.Biol., 344:1175-1181, 2004

PubMed Abstract: Triggering receptor expressed on myeloid cells (TREM) 1 is an activating receptor expressed on myeloid cells whose ligand(s) remain elusive. TREM-1 stimulation activates neutrophils and monocytes and induces the secretion of pro-inflammatory molecules, which amplifies the Toll-like receptor-initiated responses to invading pathogens. In addition, TREM-1 mediates the septic shock pathway, and thus represents a potential therapeutic target. We report the crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution. The mouse extracellular domain is monomeric, consistent with our previous human TREM-1 structure, and strongly supports the contention that the globular TREM-1 head is a monomer contrary to proposals of a symmetric dimer.

PubMed: 15561137
DOI: 10.1016/j.jmb.2004.10.009

Experimental method

X-RAY DIFFRACTION (1.76 Å)