1U8G

Crystal structure of a HIV-1 Protease in complex with peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2

Summary for 1U8G

• Entry DOI: 10.2210/pdb1u8g/pdb
• Related: 1NH0
• Related PRD ID: PRD_000401
• Descriptor: PROTEASE RETROPEPSIN, peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2 (3 entities in total)
• Functional Keywords: aspartyl protease, human immunodeficiency virus, inhibitor design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• Total number of polymer chains: 3
• Total formula weight: 22340.27

Authors

Brynda, J.,Rezacova, P.,Fabry, M.,Horejsi, M.,Hradilek, M.,Soucek, R.,Stouracova, R.,Konvalinka, J.,Sedlacek, J. (deposition date: 2004-08-06, release date: 2004-11-02, Last modification date: 2018-02-14)

• Primary citation: Brynda, J.,Rezacova, P.,Fabry, M.,Horejsi, M.,Stouracova, R.,Soucek, M.,Hradilek, M.,Konvalinka, J.,Sedlacek, J.; Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex.; Acta Crystallogr.,Sect.D, 60:1943-1948, 2004; PubMed: 15502300; DOI: 10.1107/S0907444904021572

Experimental method

X-RAY DIFFRACTION (2.201 Å)