1U72

Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH

1U72 の概要

• エントリーDOI: 10.2210/pdb1u72/pdb
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (4 entities in total)
• 機能のキーワード: wild type humand dhfr, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22549.38

構造登録者

Cody, V. (登録日: 2004-08-02, 公開日: 2005-02-01, 最終更新日: 2024-02-14)

• 主引用文献: Cody, V.,Luft, J.R.,Pangborn, W.; Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.; Acta Crystallogr.,Sect.D, 61:147-155, 2005; PubMed: 15681865; DOI: 10.1107/S0907444904030422

実験手法

X-RAY DIFFRACTION (1.9 Å)