1U65
Ache W. CPT-11
Summary for 1U65
| Entry DOI | 10.2210/pdb1u65/pdb |
| Descriptor | Acetylcholinesterase, beta-L-fucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
| Functional Keywords | torpedo ache, anticancer prodrug cpt-11, israel structural proteomics center, ispc, structural genomics, hydrolase |
| Biological source | Torpedo californica (Pacific electric ray) |
| Cellular location | Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058 |
| Total number of polymer chains | 1 |
| Total formula weight | 63599.14 |
| Authors | Harel, M.,Hyatt, J.L.,Brumshtein, B.,Morton, C.L.,Wadkins, R.W.,Silman, I.,Sussman, J.L.,Potter, P.M.,Israel Structural Proteomics Center (ISPC) (deposition date: 2004-07-29, release date: 2005-07-19, Last modification date: 2021-06-02) |
| Primary citation | Harel, M.,Hyatt, J.L.,Brumshtein, B.,Morton, C.L.,Yoon, K.J.,Wadkins, R.M.,Silman, I.,Sussman, J.L.,Potter, P.M. The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action Mol.Pharmacol., 67:1874-1881, 2005 Cited by PubMed: 15772291DOI: 10.1124/mol.104.009944 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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