1U65

Ache W. CPT-11

1U65 の概要

• エントリーDOI: 10.2210/pdb1u65/pdb
• 分子名称: Acetylcholinesterase, beta-L-fucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: torpedo ache, anticancer prodrug cpt-11, israel structural proteomics center, ispc, structural genomics, hydrolase
• 由来する生物種: Torpedo californica (Pacific electric ray)
• 細胞内の位置: Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63599.14

構造登録者

Harel, M.,Hyatt, J.L.,Brumshtein, B.,Morton, C.L.,Wadkins, R.W.,Silman, I.,Sussman, J.L.,Potter, P.M.,Israel Structural Proteomics Center (ISPC) (登録日: 2004-07-29, 公開日: 2005-07-19, 最終更新日: 2021-06-02)

• 主引用文献: Harel, M.,Hyatt, J.L.,Brumshtein, B.,Morton, C.L.,Yoon, K.J.,Wadkins, R.M.,Silman, I.,Sussman, J.L.,Potter, P.M.; The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action; Mol.Pharmacol., 67:1874-1881, 2005; PubMed: 15772291; DOI: 10.1124/mol.104.009944

実験手法

X-RAY DIFFRACTION (2.61 Å)