6D1X

N-Domain Of Grp94, with the Charged Domain, In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine

Replaces:  1U0Y

Summary for 6D1X

• Entry DOI: 10.2210/pdb6d1x/pdb
• Descriptor: Endoplasmin, N-PROPYL CARBOXYAMIDO ADENOSINE, TETRAETHYLENE GLYCOL, ... (4 entities in total)
• Functional Keywords: inhibitor, co-crystal, hsp90, chaperone
• Biological source: Canis lupus familiaris (Dog)
• Total number of polymer chains: 1
• Total formula weight: 31960.79

Authors

Gewirth, D.T.,Immormino, R.M. (deposition date: 2018-04-12, release date: 2018-05-02, Last modification date: 2023-10-04)

• Primary citation: Huck, J.D.,Que, N.L.S.,Immormino, R.M.,Shrestha, L.,Taldone, T.,Chiosis, G.,Gewirth, D.T.; NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.; J.Biol.Chem., 294:16010-16019, 2019; PubMed: 31501246; DOI: 10.1074/jbc.RA119.009960

Experimental method

X-RAY DIFFRACTION (2.3 Å)