1TZN

Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore bound to the VWA domain of CMG2, an anthrax toxin receptor

Summary for 1TZN

Entry DOI	10.2210/pdb1tzn/pdb
Related	1SHT 1TZO
Descriptor	Protective antigen, Anthrax toxin receptor 2, CALCIUM ION, ... (4 entities in total)
Functional Keywords	heptamer, toxin receptor-toxin complex, toxin receptor/toxin
Biological source	Bacillus anthracis str. More
Cellular location	Secreted, extracellular space: P13423 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P58335
Total number of polymer chains	28
Total formula weight	1161499.70
Authors	Lacy, D.B.,Wigelsworth, D.J.,Melnyk, R.A.,Collier, R.J. (deposition date: 2004-07-10, release date: 2004-08-17, Last modification date: 2024-04-03)
Primary citation	Lacy, D.B.,Wigelsworth, D.J.,Melnyk, R.A.,Harrison, S.C.,Collier, R.J. Structure of heptameric protective antigen bound to an anthrax toxin receptor: A role for receptor in pH-dependent pore formation Proc.Natl.Acad.Sci.USA, 101:13147-13151, 2004 Cited by PubMed: 15326297 DOI: 10.1073/pnas.0405405101 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.3 Å)

Structure validation