1TZE

SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2)

Summary for 1TZE

Entry DOI	10.2210/pdb1tze/pdb
Descriptor	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (3 entities in total)
Functional Keywords	signal transduction adaptor growth factor bound protein 2 (grb2) src homology 2 domain (sh2), phosphotyrosyl heptapeptic ligand, complex (signal transduction-peptide), complex (signal transduction-peptide) complex, complex (signal transduction/peptide)
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	12392.04
Authors	Rahuel, J.,Grutter, M.G. (deposition date: 1996-06-06, release date: 1997-07-07, Last modification date: 2024-06-05)
Primary citation	Rahuel, J.,Gay, B.,Erdmann, D.,Strauss, A.,Garcia-Echeverria, C.,Furet, P.,Caravatti, G.,Fretz, H.,Schoepfer, J.,Grutter, M.G. Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode. Nat.Struct.Biol., 3:586-589, 1996 Cited by PubMed: 8673601 DOI: 10.1038/nsb0796-586 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation