1TU6

Cathepsin K complexed with a ketoamide inhibitor

1TU6 の概要

• エントリーDOI: 10.2210/pdb1tu6/pdb
• 分子名称: Cathepsin K, SULFATE ION, [1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1H-PYRAZOL-5-YLAMINO)ACETYL]PENTYLCARBAMATE, ... (4 entities in total)
• 機能のキーワード: catk, cysteine protease, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P43235
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48224.15

構造登録者

Barrett, D.G.,Catalano, J.G.,Deaton, D.N.,Hassell, A.M.,Long, S.T.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Wells-Knecht, K.J.,Wright, L.L. (登録日: 2004-06-24, 公開日: 2004-09-21, 最終更新日: 2023-08-23)

• 主引用文献: Barrett, D.G.,Catalano, J.G.,Deaton, D.N.,Hassell, A.M.,Long, S.T.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Wells-Knecht, K.J.,Willard, D.H.,Wright, L.L.; Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with improved pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions; BIOORG.MED.CHEM.LETT., 14:4897-4902, 2004; PubMed: 15341947; DOI: 10.1016/j.bmcl.2004.07.031

実験手法

X-RAY DIFFRACTION (1.75 Å)