1TTM

Human carbonic anhydrase II complexed with 667-coumate

Summary for 1TTM

• Entry DOI: 10.2210/pdb1ttm/pdb
• Descriptor: Carbonic anhydrase II, ZINC ION, 6-OXO-8,9,10,11-TETRAHYDRO-7H-CYCLOHEPTA[C][1]BENZOPYRAN-3-O-SULFAMATE, ... (4 entities in total)
• Functional Keywords: cancer, human carbonic anhydrase inhibitors, 667-coumate, obesity, steroid sulfatase inhibitor, lyase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00918
• Total number of polymer chains: 1
• Total formula weight: 29598.02

Authors

Lloyd, M.D.,Pederick, R.L.,Natesh, R.,Woo, L.W.L.,Purohit, A.,Reed, M.J.,Acharya, K.R.,Potter, B.V.L. (deposition date: 2004-06-23, release date: 2004-10-05, Last modification date: 2023-08-23)

• Primary citation: Lloyd, M.D.,Pederick, R.L.,Natesh, R.,Woo, L.W.L.,Purohit, A.,Reed, M.J.,Acharya, K.R.,Potter, B.V.L.; Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent; Biochem.J., 385:715-720, 2005; PubMed: 15453828; DOI: 10.1042/BJ20041037

Experimental method

X-RAY DIFFRACTION (1.95 Å)