1TTM

Human carbonic anhydrase II complexed with 667-coumate

1TTM の概要

• エントリーDOI: 10.2210/pdb1ttm/pdb
• 分子名称: Carbonic anhydrase II, ZINC ION, 6-OXO-8,9,10,11-TETRAHYDRO-7H-CYCLOHEPTA[C][1]BENZOPYRAN-3-O-SULFAMATE, ... (4 entities in total)
• 機能のキーワード: cancer, human carbonic anhydrase inhibitors, 667-coumate, obesity, steroid sulfatase inhibitor, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29598.02

構造登録者

Lloyd, M.D.,Pederick, R.L.,Natesh, R.,Woo, L.W.L.,Purohit, A.,Reed, M.J.,Acharya, K.R.,Potter, B.V.L. (登録日: 2004-06-23, 公開日: 2004-10-05, 最終更新日: 2023-08-23)

• 主引用文献: Lloyd, M.D.,Pederick, R.L.,Natesh, R.,Woo, L.W.L.,Purohit, A.,Reed, M.J.,Acharya, K.R.,Potter, B.V.L.; Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent; Biochem.J., 385:715-720, 2005; PubMed: 15453828; DOI: 10.1042/BJ20041037

実験手法

X-RAY DIFFRACTION (1.95 Å)