1TSI

STRUCTURE OF THE COMPLEX BETWEEN TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AND N-HYDROXY-4-PHOSPHONO-BUTANAMIDE: BINDING AT THE ACTIVE SITE DESPITE AN "OPEN" FLEXIBLE LOOP

Summary for 1TSI

Entry DOI	10.2210/pdb1tsi/pdb
Descriptor	TRIOSEPHOSPHATE ISOMERASE, N-HYDROXY-4-PHOSPHONO-BUTANAMIDE (3 entities in total)
Functional Keywords	isomerase(intramolecular oxidoreductase)
Biological source	Trypanosoma brucei brucei
Cellular location	Glycosome: P04789
Total number of polymer chains	2
Total formula weight	54084.98
Authors	Verlinde, C.L.M.J. (deposition date: 1992-11-19, release date: 1994-01-31, Last modification date: 2024-02-14)
Primary citation	Verlinde, C.L.,Witmans, C.J.,Pijning, T.,Kalk, K.H.,Hol, W.G.,Callens, M.,Opperdoes, F.R. Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop conformation. Protein Sci., 1:1578-1584, 1992 Cited by PubMed: 1304889 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.84 Å)

Structure validation