1TRG

E. COLI THYMIDYLATE SYNTHASE IN SYMMETRIC COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)

1TRG の概要

• エントリーDOI: 10.2210/pdb1trg/pdb
• 分子名称: THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total)
• 機能のキーワード: methyltransferase, symmetric ternary complex
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P0A884
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31329.31

構造登録者

Stout, T.J.,Sage, C.R.,Stroud, R.M. (登録日: 1998-05-21, 公開日: 1998-08-12, 最終更新日: 2023-08-09)

主引用文献

Stout, T.J.,Sage, C.R.,Stroud, R.M.
The additivity of substrate fragments in enzyme-ligand binding.
Structure, 6:839-848, 1998

PubMed Abstract: Enzymes have evolved to recognise their target substrates with exquisite selectivity and specificity. Whether fragments of the substrate--perhaps never available to the evolving enzyme--are bound in the same manner as the parent substrate addresses the fundamental basis of specificity. An understanding of the relative contributions of individual portions of ligand molecules to the enzyme-binding interaction may offer considerable insight into the principles of substrate recognition.

PubMed: 9687366
DOI: 10.1016/S0969-2126(98)00086-0

実験手法

X-RAY DIFFRACTION (1.9 Å)