1TQF

Crystal structure of human Beta secretase complexed with inhibitor

Summary for 1TQF

Entry DOI	10.2210/pdb1tqf/pdb
Descriptor	Beta-secretase 1, 3-{2-[(5-AMINOPENTYL)AMINO]-2-OXOETHOXY}-5-({[1-(4-FLUOROPHENYL)ETHYL]AMINO}CARBONYL)PHENYL PHENYLMETHANESULFONATE (3 entities in total)
Functional Keywords	aspartyl protease, bace, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	1
Total formula weight	45694.41
Authors	Munshi, S.,Chen, Z.,Kuo, L. (deposition date: 2004-06-17, release date: 2004-11-09, Last modification date: 2023-08-23)
Primary citation	Coburn, C.A.,Stachel, S.J.,Li, Y.M.,Rush, D.M.,Steele, T.G.,Chen-Dodson, E.,Holloway, M.K.,Xu, M.,Huang, Q.,Lai, M.T.,DiMuzio, J.,Crouthamel, M.C.,Shi, X.P.,Sardana, V.,Chen, Z.,Munshi, S.,Kuo, L.,Makara, G.M.,Annis, D.A.,Tadikonda, P.K.,Nash, H.M.,Vacca, J.P.,Wang, T. Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases. J.Med.Chem., 47:6117-6119, 2004 Cited by PubMed: 15566281 DOI: 10.1021/jm049388p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation