1TLS
THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH FDUMP AND METHYLENETETRAHYDROFOLATE
Summary for 1TLS
Entry DOI | 10.2210/pdb1tls/pdb |
Descriptor | THYMIDYLATE SYNTHASE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, ... (4 entities in total) |
Functional Keywords | transferase, methyltransferase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 62690.59 |
Authors | Hyatt, D.C.,Maley, F.,Montfort, W.R. (deposition date: 1996-12-03, release date: 1997-07-07, Last modification date: 2024-04-03) |
Primary citation | Hyatt, D.C.,Maley, F.,Montfort, W.R. Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate. Biochemistry, 36:4585-4594, 1997 Cited by PubMed: 9109668DOI: 10.1021/bi962936j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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