1TL8

Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex

1TL8 の概要

• エントリーDOI: 10.2210/pdb1tl8/pdb
• 関連するPDBエントリー: 1K4t
• 分子名称: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TPC)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ... (5 entities in total)
• 機能のキーワード: complex (isomerase-dna), dna, topoisomerase i, drug, poison, idenoisoquinoline, isomerase-dna complex, isomerase/dna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus, nucleolus: P11387
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 84038.30

構造登録者

Ioanoviciu, A.,Antony, S.,Pommier, Y.,Staker, B.L.,Stewart, L.,Cushman, M. (登録日: 2004-06-09, 公開日: 2005-06-21, 最終更新日: 2011-07-13)

• 主引用文献: Ioanoviciu, A.,Antony, S.,Pommier, Y.,Staker, B.L.,Stewart, L.,Cushman, M.; Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis; J.Med.Chem., 48:4803-4814, 2005; PubMed: 16033260; DOI: 10.1021/jm050076b

実験手法

X-RAY DIFFRACTION (3.1 Å)