1TKT

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318

Summary for 1TKT

Entry DOI	10.2210/pdb1tkt/pdb
Descriptor	Pol polyproteins [Reverse transcriptase], Chain A, Pol polyproteins [Reverse transcriptase], Chain B, PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	hiv-1 reverse transcriptase, aids, nnrti, gw426318, drug design, transferase
Biological source	Human immunodeficiency virus 1 More
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
Total number of polymer chains	2
Total formula weight	116623.04
Authors	Hopkins, A.L.,Ren, J.,Stuart, D.I.,Stammers, D.K. (deposition date: 2004-06-09, release date: 2004-12-07, Last modification date: 2018-01-31)
Primary citation	Hopkins, A.L.,Ren, J.,Milton, J.,Hazen, R.J.,Chan, J.H.,Stuart, D.I.,Stammers, D.K. Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. J.Med.Chem., 47:5912-5922, 2004 Cited by PubMed: 15537346 DOI: 10.1021/jm040071z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation