1TKT

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318

1TKT の概要

• エントリーDOI: 10.2210/pdb1tkt/pdb
• 分子名称: Pol polyproteins [Reverse transcriptase], Chain A, Pol polyproteins [Reverse transcriptase], Chain B, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase, aids, nnrti, gw426318, drug design, transferase
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116623.04

構造登録者

Hopkins, A.L.,Ren, J.,Stuart, D.I.,Stammers, D.K. (登録日: 2004-06-09, 公開日: 2004-12-07, 最終更新日: 2018-01-31)

• 主引用文献: Hopkins, A.L.,Ren, J.,Milton, J.,Hazen, R.J.,Chan, J.H.,Stuart, D.I.,Stammers, D.K.; Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.; J.Med.Chem., 47:5912-5922, 2004; PubMed: 15537346; DOI: 10.1021/jm040071z

実験手法

X-RAY DIFFRACTION (2.6 Å)