1TIT

TITIN, IG REPEAT 27, NMR, MINIMIZED AVERAGE STRUCTURE

Summary for 1TIT

• Entry DOI: 10.2210/pdb1tit/pdb
• Descriptor: TITIN, I27 (1 entity in total)
• Functional Keywords: muscle protein, immunoglobulin-like domain
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 10928.43

Authors

Improta, S.,Politou, A.S.,Pastore, A. (deposition date: 1996-02-02, release date: 1996-07-11, Last modification date: 2024-05-22)

Primary citation

Improta, S.,Politou, A.S.,Pastore, A.
Immunoglobulin-like modules from titin I-band: extensible components of muscle elasticity.
Structure, 4:323-337, 1996

PubMed Abstract: The giant muscle protein titin forms a filament which spans half of the sarcomere and performs, along its length, quite diverse functions. The region of titin located in the sarcomere I-band is believed to play a major role in extensibility and passive elasticity of muscle. In the I-band, the titin sequence consists mostly of repetitive motifs of tandem immunoglobulin-like (Ig) modules intercalated by a potentially non-globular region. The highly repetitive titin architecture suggests that the molecular basis of its mechanical properties be approached through the characterization of the isolated components of the I-band and their interfaces. In the present paper, we report on the structure determination in solution of a representative Ig module from the I-band (I27) as solved by NMR techniques.

PubMed: 8805538
DOI: 10.1016/S0969-2126(96)00036-6

Experimental method

SOLUTION NMR