1TFT
NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP
Summary for 1TFT
Entry DOI | 10.2210/pdb1tft/pdb |
Related | 1g3f 1tfq |
Descriptor | Baculoviral IAP repeat-containing protein 4, ZINC ION, 1-[3,3-DIMETHYL-2-(2-METHYLAMINO-PROPIONYLAMINO)-BUTYRYL]-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMIDE (3 entities in total) |
Functional Keywords | complex, ligand-protein, apoptosis, bir, xiap |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P98170 |
Total number of polymer chains | 1 |
Total formula weight | 14025.05 |
Authors | Oost, T.K.,Sun, C.,Armstrong, R.C.,Al-Assaad, A.S.,Betz, S.F.,Deckwerth, T.L.,Elmore, S.W.,Meadows, R.P.,Olejniczak, E.T.,Oleksijew, A.K.,Oltersdorf, T.,Rosenberg, S.H.,Shoemaker, A.R.,Zou, H.,Fesik, S.W. (deposition date: 2004-05-27, release date: 2005-05-03, Last modification date: 2022-03-02) |
Primary citation | Oost, T.K.,Sun, C.,Armstrong, R.C.,Al-Assaad, A.S.,Betz, S.F.,Deckwerth, T.L.,Ding, H.,Elmore, S.W.,Meadows, R.P.,Olejniczak, E.T.,Oleksijew, A.K.,Oltersdorf, T.,Rosenberg, S.H.,Shoemaker, A.R.,Tomaselli, K.J.,Zou, H.,Fesik, S.W. Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J.Med.Chem., 47:4417-4426, 2004 Cited by PubMed: 15317454DOI: 10.1021/jm040037k PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report