1TFQ
NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP
Summary for 1TFQ
Entry DOI | 10.2210/pdb1tfq/pdb |
Related | 1TFT |
Descriptor | Baculoviral IAP repeat-containing protein 4, ZINC ION, N-METHYLALANYL-3-METHYLVALYL-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE (3 entities in total) |
Functional Keywords | complex, ligand-protein, apoptosis, bir, xiap |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P98170 |
Total number of polymer chains | 1 |
Total formula weight | 13932.95 |
Authors | Oost, T.K.,Sun, C.,Armstrong, R.C.,Al-Assaad, A.S.,Betz, S.F.,Deckwerth, T.L.,Elmore, S.W.,Meadows, R.P.,Olejniczak, E.T.,Oleksijew, A.,Oltersdorf, T.,Rosenberg, S.H.,Shoemaker, A.R.,Zou, H.,Fesik, S.W. (deposition date: 2004-05-27, release date: 2004-09-07, Last modification date: 2024-05-22) |
Primary citation | Oost, T.K.,Sun, C.,Armstrong, R.C.,Al-Assaad, A.S.,Betz, S.F.,Deckwerth, T.L.,Ding, H.,Elmore, S.W.,Meadows, R.P.,Olejniczak, E.T.,Oleksijew, A.,Oltersdorf, T.,Rosenberg, S.H.,Shoemaker, A.R.,Tomaselli, K.J.,Zou, H.,Fesik, S.W. Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer. J.Med.Chem., 47:4417-4426, 2004 Cited by PubMed: 15317454DOI: 10.1021/jm040037k PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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