1TF3

TFIIIA FINGER 1-3 BOUND TO DNA, NMR, 22 STRUCTURES

1TF3 の概要

• エントリーDOI: 10.2210/pdb1tf3/pdb
• 分子名称: 5S RNA GENE, TRANSCRIPTION FACTOR IIIA, ZINC ION, ... (4 entities in total)
• 機能のキーワード: tfiiia, protein, dna, transcription factor, 5s rna gene, dna binding protein, zinc finger, complex (transcription regulation-dna), transcription-dna complex, transcription/dna
• 由来する生物種: Xenopus laevis (African clawed frog); 詳細
• 細胞内の位置: Nucleus: P03001
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 20062.42

構造登録者

Foster, M.P.,Wuttke, D.S.,Radhakrishnan, I.,Case, D.A.,Gottesfeld, J.M.,Wright, P.E. (登録日: 1997-07-01, 公開日: 1997-09-17, 最終更新日: 2024-05-22)

主引用文献

Foster, M.P.,Wuttke, D.S.,Radhakrishnan, I.,Case, D.A.,Gottesfeld, J.M.,Wright, P.E.
Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA.
Nat.Struct.Biol., 4:605-608, 1997

PubMed Abstract: The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

PubMed: 9253405
DOI: 10.1038/nsb0897-605

実験手法

SOLUTION NMR