1T4J
Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
Summary for 1T4J
Entry DOI | 10.2210/pdb1t4j/pdb |
Related | 1PTY 1T48 1T49 2HNP |
Descriptor | Protein-tyrosine phosphatase, non-receptor type 1, 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID [4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE (2 entities in total) |
Functional Keywords | allosteric inhibition protein tyrosine phosphatase 1b, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35462.01 |
Authors | Wiesmann, C.,Barr, K.J.,Kung, J.,Zhu, J.,Shen, W.,Fahr, B.J.,Zhong, M.,Taylor, L.,Randal, M.,McDowell, R.S.,Hansen, S.K. (deposition date: 2004-04-29, release date: 2004-07-20, Last modification date: 2024-02-14) |
Primary citation | Wiesmann, C.,Barr, K.J.,Kung, J.,Zhu, J.,Erlanson, D.A.,Shen, W.,Fahr, B.J.,Zhong, M.,Taylor, L.,Randal, M.,McDowell, R.S.,Hansen, S.K. Allosteric inhibition of protein tyrosine phosphatase 1B Nat.Struct.Mol.Biol., 11:730-737, 2004 Cited by PubMed: 15258570DOI: 10.1038/nsmb803 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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