1T2S
Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain
Summary for 1T2S
| Entry DOI | 10.2210/pdb1t2s/pdb |
| Related | 1t2s 1UPO |
| Descriptor | 5'-D(*CP*TP*CP*AP*C)-3', Argonaute 2 (2 entities in total) |
| Functional Keywords | nucleic acid binding protein, dna, nucleic acid binding protein-dna complex, nucleic acid binding protein/dna |
| Biological source | Drosophila melanogaster (fruit fly) |
| Total number of polymer chains | 2 |
| Total formula weight | 15368.96 |
| Authors | Lingel, A.,Simon, B.,Izaurralde, E.,Sattler, M. (deposition date: 2004-04-22, release date: 2004-06-01, Last modification date: 2024-05-22) |
| Primary citation | Lingel, A.,Simon, B.,Izaurralde, E.,Sattler, M. Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat.Struct.Mol.Biol., 11:576-577, 2004 Cited by PubMed Abstract: We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs. PubMed: 15156196DOI: 10.1038/nsmb777 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
Download full validation report
