1T15

Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase

1T15 の概要

• エントリーDOI: 10.2210/pdb1t15/pdb
• 分子名称: Breast cancer type 1 susceptibility protein, BRCA1 interacting protein C-terminal helicase 1 (3 entities in total)
• 機能のキーワード: protein-peptide complex, antitumor protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus. Isoform 3: Cytoplasm. Isoform 5: Cytoplasm: P38398
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25493.16

構造登録者

Clapperton, J.A.,Manke, I.A.,Lowery, D.M.,Ho, T.,Haire, L.F.,Yaffe, M.B.,Smerdon, S.J. (登録日: 2004-04-15, 公開日: 2004-05-11, 最終更新日: 2011-07-13)

• 主引用文献: Clapperton, J.A.,Manke, I.A.,Lowery, D.M.,Ho, T.,Haire, L.F.,Yaffe, M.B.,Smerdon, S.J.; Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer; Nat.Struct.Mol.Biol., 11:512-518, 2004; PubMed: 15133502; DOI: 10.1038/nsmb775

実験手法

X-RAY DIFFRACTION (1.85 Å)