1SYN

E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)

1SYN の概要

• エントリーDOI: 10.2210/pdb1syn/pdb
• 分子名称: THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, ... (4 entities in total)
• 機能のキーワード: transferase (methyltransferase)
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P0A884
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62704.69

構造登録者

Stout, T.J.,Stroud, R.M. (登録日: 1995-09-19, 公開日: 1996-01-29, 最終更新日: 2011-07-13)

• 主引用文献: Stout, T.J.,Stroud, R.M.; The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.; Structure, 4:67-77, 1996; PubMed: 8805515; DOI: 10.1016/S0969-2126(96)00010-X

実験手法

X-RAY DIFFRACTION (2 Å)