1SY6

Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment

1SY6 の概要

• エントリーDOI: 10.2210/pdb1sy6/pdb
• 分子名称: OKT3 Fab light chain, OKT3 Fab heavy chain, T-cell surface glycoprotein CD3 gamma/epsilon chain (3 entities in total)
• 機能のキーワード: cd3 gamma, cd3 epsilon, okt3 fab, signaling protein-antibiotic complex, signaling protein/antibiotic
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P07766
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70159.85

構造登録者

Kjer-Nielsen, L.,Dunstone, M.A.,Kostenko, L.,Ely, L.K.,Beddoe, T.,Misfud, N.A.,Purcell, A.W.,Brooks, A.G.,McCluskey, J.,Rossjohn, J. (登録日: 2004-03-31, 公開日: 2004-05-25, 最終更新日: 2018-04-04)

• 主引用文献: Kjer-Nielsen, L.,Dunstone, M.A.,Kostenko, L.,Ely, L.K.,Beddoe, T.,Mifsud, N.A.,Purcell, A.W.,Brooks, A.G.,McCluskey, J.,Rossjohn, J.; Crystal structure of the human T cell receptor CD3(epsilon)(gamma) heterodimer complexed to the therapeutic mAb OKT3.; Proc.Natl.Acad.Sci.USA, 101:7675-7680, 2004; PubMed: 15136729; DOI: 10.1073/pnas.0402295101

実験手法

X-RAY DIFFRACTION (2.1 Å)